Neurontin high

Renal Impairment Dosage adjustment in high adult patients high with compromised renal function is high necessary see Dosage and neurontin Administration (2.3) and neurontin Clinical Pharmacology (12.3). Neurontin high - Clinical Pharmacology Mechanism of Action The high precise mechanisms by which gabapentin high produces its analgesic and antiepileptic actions are unknown. Neurontin Dosage Based on Renal Function. Stopping a seizure medicine suddenly in high a patient who has epilepsy can cause seizures that will not stop (status epilepticus). Adverse Reactions The high following neurontin anxiety serious adverse reactions are discussed in greater detail in other neurontin sections: Clinical Trials Experience Because clinical trials are conducted under widely neurontin varying conditions, adverse reaction rates observed in the neurontin clinical trials of a drug. Only at high the high highest concentration tested (171 mcg/mL; 1 mM) was neurontin a slight degree of inhibition (14 to neurontin 30) of isoform CYP2A6 observed. The neurontin most common adverse reactions with Neurontin in combination with other antiepileptic drugs in pediatric patients high 3 neurontin dosage to 12 years high of age, not seen at an equal frequency among placebo-treated patients, were viral infection, fever, nausea and/or vomiting, somnolence, high and. Apparent oral clearance of gabapentin was directly proportional to creatinine clearance. Do not take Neurontin if you are allergic to gabapentin or any of the other ingredients in Neurontin. Naproxen Coadministration (N18) of naproxen sodium capsules (250 mg) with Neurontin (125 mg) appears to increase the amount of gabapentin absorbed by 12. In controlled clinical epilepsy trials in pediatric patients 3 to 12 years of age, the incidence of these adverse reactions was: emotional lability 6 (gabapentin-treated patients) versus.3 (placebo-treated patients hostility.2 versus.3; hyperkinesia.7 versus.9; and thought disorder.7 versus. The adverse reactions that most frequently led to withdrawal in Neurontin-treated patients were dizziness, somnolence, and nausea. Elimination Gabapentin is eliminated from the systemic circulation high by renal excretion as unchanged drug. Modeling provided high confirmatory evidence of efficacy across all doses. The 300-mg capsule high shell also contains: yellow iron oxide. You can ask your healthcare provider or pharmacist for information about Neurontin that was written for healthcare professionals. Dizziness and somnolence were among the most common adverse reactions leading to discontinuation of Neurontin. No inhibition of any of the other isoforms tested was observed at gabapentin concentrations up to 171 mcg/mL (approximately 15 times high the Cmax at 3600 mg/day). The adverse reactions most commonly associated with withdrawal in pediatric patients were emotional lability (1.6 hostility high (1.3 and hyperkinesia (1.1). Whether the impairment is related to somnolence see Warnings and Precautions (5.4) or other effects of Neurontin is unknown. The magnitude of interaction at other doses is not known. In patients with stable renal function, creatinine clearance can be reasonably well estimated using the equation of Cockcroft and Gault: The use of Neurontin in patients less than neurontin 12 years of age with compromised renal function has not been studied. When prescribing gabapentin carefully evaluate patients for a history of drug abuse and observe them for signs and symptoms of gabapentin misuse or abuse (e.g., development of tolerance, self-dose escalation, and drug-seeking behavior). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. A response ratio of -0.33 corresponds to a 50 neurontin reduction in seizure frequency. The normalized CL/F values observed in pediatric patients 5 years of age and older were consistent with values observed in adults after a single dose. Call a healthcare provider right high away if you have any of the following symptoms: skin rash hives difficulty breathing fever swollen glands that do not go away swelling high of your face, lips, throat, or tongue yellowing. Dependence There are rare postmarketing reports of individuals experiencing withdrawal symptoms shortly after discontinuing higher than recommended doses of gabapentin used neurontin to treat illnesses for which the drug is not approved. What should neurontin I tell my healthcare provider before taking Neurontin? Responder rate was 23 (14/61) in the Neurontin group and 9 (6/66) in the placebo group; high the difference between groups was statistically significant. Do not stop taking Neurontin without first talking to a healthcare provider. Patients 12 years of age and above. You can enroll in this registry by calling. Should suicidal thoughts high and behavior neurontin emerge during treatment, the prescriber needs to consider whether the emergence of these symptoms in any given patient may be related to the illness being treated. The no-effect dose for embryofetal developmental toxicity in mice (500 mg/kg/day) is less than the maximum recommended human dose (mrhd) of 3600 mg on a body surface area (mg/m2) neurontin basis. Each Neurontin capsule contains 100 mg, 300 mg, or 400 mg of gabapentin and the following inactive neurontin ingredients: lactose, cornstarch, talc, gelatin, titanium dioxide, FD C Blue. Comparable treatment effects were observed in all active treatment arms. Suicidal Thinking and Behavior Counsel the patient, their caregivers, and families that AEDs, including Neurontin, may increase the risk of suicidal thoughts and behavior. Responder Rate in Patients Receiving Neurontin Expressed as a Difference from Placebo by Dose and Study: Adjunctive Therapy Studies in Patients 12 Years of Age with Partial Seizures In the figure, treatment effect magnitude, measured. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (gaba) but has no effect on gaba binding, uptake, or degradation. Apparent oral clearance (CL/F) was directly proportional to creatinine clearance and this relationship was similar following a single dose and at steady-state. Tumorigenic Potential In an oral carcinogenicity study, gabapentin increased the incidence of pancreatic acinar cell tumors in rats high see Nonclinical Toxicology (13.1). Adverse Reactions in a Placebo-Controlled Add-On Trial in Pediatric Epilepsy Patients Age 3 to 12 Years Neurontin N119 neurontin Placebo * N128 Body As A Whole Viral Infection 11 3 Fever 10 3 Increased Weight 3 1 Fatigue. An additional Neurontin 1200 mg/day dosage group (N52) provided dose-response data. A small number of postmarketing cases report gabapentin misuse and abuse. In these studies, either Neurontin or placebo was added to the patient's current antiepileptic drug therapy. Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. Hepatobiliary disorders: jaundice Investigations: elevated creatine kinase, elevated liver function tests Metabolism and nutrition disorders: hyponatremia Musculoskeletal and connective tissue disorder: rhabdomyolysis high Nervous system disorders: movement disorder neurontin Psychiatric disorders: agitation Reproductive system and breast disorders: breast enlargement, changes in libido. Dizziness and Somnolence and Effects on Driving and Operating Heavy Machinery Advise patients that Neurontin may cause dizziness, somnolence, and other symptoms and signs of CNS depression. Adjunctive therapy in the treatment of partial onset seizures, with and without secondary neurontin generalization, in adults and pediatric patients 3 years and older with epilepsy. Neurontin Description The active ingredient in Neurontin capsules, tablets, and oral solution is gabapentin, neurontin which has the chemical name acid. If you take an antacid containing aluminum and magnesium, such as Maalox, Mylanta, Gelusil, Gaviscon, or Di-Gel, you should high wait at least 2 hours before taking your next dose of Neurontin. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy. Stopping Neurontin suddenly can cause serious problems. If you take Neurontin tablets and break a tablet in half, the unused half of the tablet should be taken at your next scheduled dose. In studies in which rats received oral doses of gabapentin (500 to 2000 mg/kg/day) during pregnancy, adverse effect on offspring development (increased incidences of hydroureter and/or hydronephrosis) were observed at all doses. Drug Interactions In Vitro Studies In vitro studies were conducted to investigate the potential of gabapentin to inhibit the major cytochrome P450 enzymes (CYP1A2, neurontin CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4) that mediate drug and xenobiotic metabolism using isoform selective. Signs and symptoms in reported cases have included difficulty breathing, swelling of the lips, throat, and tongue, and hypotension requiring emergency treatment. Dosage for Epilepsy with Partial Onset Seizures. The types and incidence of adverse reactions were similar across age groups except for peripheral edema and ataxia, which tended to increase in incidence with age. At 2000 mg/kg, the plasma neurontin gabapentin exposure (AUC) in mice was approximately 2 times that in humans at the mrhd of 3600 mg/day. However, other factors cannot be excluded. A mean pain score during baseline of at least 4 high was required for randomization. Advise patients of the need to be alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm. Because gabapentin is primarily renally excreted and there are no important racial differences in creatinine clearance, pharmacokinetic differences due to race are not expected. Inform patients that, should they divide the scored 600 mg or 800 neurontin mg Neurontin tablet in order to administer a half-tablet, they should take the unused half-tablet as the next dose. Dosages up to 2400 mg/day have been well tolerated in long-term clinical studies. In nonclinical studies in mice, rats, and rabbits, gabapentin was developmentally toxic (increased fetal skeletal and visceral abnormalities, and increased embryofetal mortality) when administered to pregnant animals at doses similar to or lower than those used clinically see Data. Because only 3 of patients (28/921) in placebo-controlled studies were identified as nonwhite (black or other there are insufficient data neurontin to support a statement regarding the distribution of adverse reactions by race. When pregnant rabbits were treated with gabapentin during the period of organogenesis, an increase in embryofetal mortality was observed at all doses tested (60, 300, or 1500 mg/kg). Changes in behavior and thinking - Using Neurontin in children 3 to 12 years of age can cause emotional changes, aggressive behavior, problems with concentration, restlessness, changes in school performance, and hyperactivity. The starting dose range is 10 mg/kg/day to 15 mg/kg/day, given in three divided doses, and the recommended maintenance neurontin dose reached by upward titration over a period of approximately 3 days. Sudden and Unexplained Death in Patients with Epilepsy During the course of premarketing development of Neurontin, 8 sudden and unexplained deaths were recorded among a cohort of 2203 epilepsy patients treated (2103 patient-years of exposure) with Neurontin. In patients continuing to have at least 2 (or 4 in some studies) seizures per month, Neurontin or placebo was then added on to the existing therapy during a 12-week treatment period. There were several response ratio comparisons that showed a statistically significant advantage for Neurontin compared to placebo and favorable trends for almost all comparisons. In these cases, double vision, slurred speech, drowsiness, lethargy, and diarrhea were observed. A third study compared Neurontin 900 mg/day, in three divided doses (N111 and placebo (N109). The lowest dose tested is similar to the mrhd on a mg/m2 basis. Patients received 10 to 65 mg/kg/day given three times a day. Anaphylaxis and Angioedema Advise patients to discontinue Neurontin and seek medical care if they develop signs or symptoms of anaphylaxis or angioedema see Warnings and Precautions (5.2). Know the medicines high you take. Gender Although no formal study has been conducted to compare the pharmacokinetics of gabapentin in men and women, it appears that the pharmacokinetic parameters for males and females are similar and there are no significant gender differences. Gabapentin elimination half-life is 5 to 7 hours and is unaltered by dose or following multiple dosing. The risk of suicidal thoughts or behavior was generally consistent among drugs in the data analyzed. Food and Drug Administration. Some of these reactions have been fatal or life-threatening. Neurontin should be discontinued if an alternative etiology for the signs or symptoms cannot be established. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine. Distribution Less than 3 of gabapentin circulates bound to plasma protein. This may cause you to be hospitalized or to stop Neurontin. In general, pediatric subjects between 1 month and 5 years of age achieved approximately 30 lower exposure (AUC) than that observed in those 5 years of age and older. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. At 2000 mg/kg, the plasma gabapentin exposure (AUC) in rats is approximately 8 times that in humans at the mrhd. Each Neurontin tablet contains 600 mg or 800 mg of gabapentin and the following inactive ingredients: poloxamer 407, copovidone, cornstarch, magnesium stearate, hydroxypropyl cellulose, talc, and candelilla wax Neurontin oral solution contains 250 mg of gabapentin. The risk did not vary substantially by age (5100 years) in the clinical trials analyzed. The recommended maintenance dose of Neurontin in patients 3 to 4 years of age is 40 mg/kg/day, given in three divided doses. Discontinuation of gabapentin treatment occurred.3 of patients reporting emotional lability and hyperkinesia and.9 of gabapentin-treated patients reporting hostility and thought disorder. Accordingly, although patients' ability to determine their level of impairment can be unreliable, advise them neither to drive a car nor to operate other complex machinery until they have gained sufficient experience on Neurontin to gauge whether or not. Oral Bioavailability Gabapentin bioavailability is not dose proportional;.e., as dose is increased, bioavailability decreases. Apparent oral clearance (CL/F) of gabapentin decreased as age increased, from about 225 mL/min in those under 30 years of age to about 125 mL/min in those over 70 years of age. Adverse Reactions in Pooled Placebo-Controlled Add-On Trials In Epilepsy Patients 12 years of age Neurontin N543 Placebo * N378 Body As A Whole Fatigue 11 5 Increased Weight 3 2 Back Pain 2 1 Peripheral Edema 2 1 Cardiovascular Vasodilatation. The duration of driving impairment after starting therapy with Neurontin is unknown. Dosages up to 50 mg/kg/day have been well tolerated in a long-term clinical study. The overall incidence of adverse reactions and the types of adverse reactions seen were similar among men and women treated with Neurontin. Pediatric Patients Age 3 to 11 years. Cimetidine In the presence of cimetidine at 300 mg four times a day (N12 the mean apparent oral clearance of gabapentin fell by 14 and creatinine clearance fell. One placebo-treated patient (0.4) withdrew due to emotional lability. Patients, their caregivers, and families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of the signs and symptoms. How should I store Neurontin? Because adequate historical data are not available, it is impossible to say whether or not treatment with Neurontin is associated with a higher or lower rate of status epilepticus than would be expected to occur in a similar population not treated with Neurontin. It is freely soluble in water and both basic and acidic aqueous solutions. Without knowledge of the background incidence and recurrence in a similar population not treated with Neurontin, it is impossible to know whether the incidence seen in this cohort is or is not affected by treatment. Additional smaller Neurontin dosage groups (600 mg/day, N53; 1800 mg/day, N54) were also studied for information regarding dose response. Coma, neurontin resolving with dialysis, has been reported in patients with chronic renal failure who were treated with Neurontin. Response ratio was also better in the Neurontin group (-0.199) than in the placebo group (-0.044 a difference that also achieved statistical significance. For all partial seizures in the intent-to-treat population, the response ratio was statistically significantly better for the Neurontin group (-0.146) than for the placebo group (-0.079). Gabapentin has been shown in vitro to interfere with activity of the 2 subunit of voltage-activated calcium high channels, a receptor involved in neuronal synaptogenesis. Table 2 shows absolute and relative risk by indication for all evaluated AEDs. The clinical significance of this finding is unknown. Postherpetic Neuralgia The most common adverse reactions associated with the use of Neurontin in adults, not seen at an equivalent frequency among placebo-treated patients, were dizziness, somnolence, and peripheral edema. For more information go to m or call. Gabapentin elimination rate constant, plasma clearance, and renal clearance are directly proportional to creatinine clearance. In vitro studies have shown that gabapentin binds with high-affinity to the 2 subunit of voltage-activated calcium channels; however, the relationship of this binding neurontin to the therapeutic effects of gabapentin is unknown. Both studies demonstrated efficacy compared to placebo at all doses tested. The dependence and abuse potential of gabapentin has not been evaluated in human studies.

What is neurontin

Pharmacodynamics Crestor dose dependently reduces elevated LDL-cholesterol and what reduces total cholesterol and triglycerides and increases HDL-cholesterol see Clinical Studies (14). It "is widely used for neurontin the neurontin treatment of different heart and vascular diseases, as well as for the improvement of work capacity of healthy people at physical and mental overloads and during rehabilitation period depending on the dosage prescribed, Grindeks adds. Lippi G, neurontin Mattiuzzi C (June 2016). Free 4 pills with what every order! This, what in summary, shows that meldonium given neurontin in acute doses could be beneficial for the treatment of seizures and alcohol intoxication. Nearly two dozen countries worldwide have announced a recall for generic Diovan, indicating that impurities were detected in the hypertension and heart drug that may cause cancer. "Q A: Meldonium, the drug in Russia's Olympic doping case". Crestor dosage should be adjusted in Asian patients see Dosage and Administration (2.3) and Clinical Pharmacology (12.3). Concomitant Use Of nexium With. Who should not take Crestor? We would also suggest some other options to talk over with your physician. Since then Ive always had very serious, reoccurring cramps in the front of my thigh(s). If your doctor tells you to stop taking bactrim, or what the tablets or oral suspension has passed its expiry date, ask your pharmacist what to do with any medicine that. You may need to take Crestor on a long-term basis. Hepatic Impairment Crestor is contraindicated in patients with active liver disease, which may include unexplained persistent elevations of hepatic transaminase levels. Tizanidine neurontin zanaflex ) is used to treat neurontin muscle spasms caused by what certain. Common Side Effects of, effexor Patients taking Effexor have reported a host of side effects. You should not use Bactrim if you have severe liver or kidney disease, anemia caused by folic acid deficiency,. Lipitor, many people may wonder what the difference is between. Prednisone withdrawal occurs when a person stops taking prednisone abruptly or reduces their dose too quickly. The rupture or clot causes. If these rare effects occur, talk to your doctor. Coli resistance to ciprofloxacin is increasing, and that the medical community should consider restricting the use of this antibiotic. Surprisingly, Sharapova is very much aware of meldonium effects, because she has actually been taking the drug for the past 10 yearsit was only just added to the World Anti-Doping Agencys (Wada) list of banned substances on January 1 of this year. There is also evidence to suggest that meldonium could be equally beneficial under the low oxygen conditions induced by intense endurance exercise. The dose of Crestor should not exceed 10 mg once daily see Warnings and Precautions (5.1), Drug Interactions what (7.3) and Clinical Pharmacology (12.3). Interactions With Diagnostic Investigations For Neuroendocrine Tumors Serum chromogranin A (CgA) levels increase secondary to drug-induced decreases in gastric acidity. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Doing so may allow the infection to return and potentially be worse. Some of the dosage forms listed on this page may not apply to the brand name. One reader reported muscle cramps: I am 57 neurontin years old. Indication, dosage Regimen, highly, emetogenic, cancer Chemotherapy, a single 24-mg dose administered 30 minutes before the start of single-day highly emetogenic chemotherapy, including cisplatin greater than or equal to 50 mg/m2. Dosage Forms and Strengths 5 mg: Yellow, round, biconvex, coated tablets. There have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins, including rosuvastatin. One patient had a baseline. Use with Concomitant Therapy Patients taking cyclosporine The dose of Crestor should not exceed 5 mg once daily see Warnings and Precautions (5.1), Drug Interactions (7.1) and Clinical Pharmacology (12.3).

Neurontin dosage

Elderly patients are dosage at higher risk of myopathy and neurontin Crestor should dosage be dosage prescribed with dosage caution in the elderly see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3). Mean baseline ldlc: 189 mg/dL Table. You may feel better before you finish your course of treatment, but you should keep taking your medication as directed. Do not take Crestor if you: are allergic to rosuvastatin calcium or any of the ingredients in Crestor. Sildenafil (Viagra, Revatio) is a moderately priced drug used to treat erection problems in is also used to treat pulmonary arterial hypertension, a serious heart and lung condition. Related: Maria Sharapova Fails Drug Test, Prompting Nike to Suspend Relationship "That sounds reasonable Catlin, the former director of the.S. When flying, never put it into a checked bag. These drugs may change the way Cipro works, which could be harmful or cause serious side effects. 626 Omeprazole 20.5.6 3 568 nexium 40.4.9.S. Cataracts were seen in dogs treated for 12 weeks by oral gavage at 30 mg/kg/day (systemic exposures 60 times the human exposure at 40 dosage mg/day based on AUC). Doxycycline is in a class of medications called dosage tetracyclines, and it's a broad-spectrum antibiotic, which means it works against a wide range of bacteria. Other drugs may interact with doxycycline, including prescription and over-the-counter medicines, vitamins, and herbal products. You should take this medication only to treat bacterial infections, and it's important to take it exactly as your doctor prescribes. Zanaflex dosage tablets are supplied as 4 mg tablets for oral administration. Fraenkel G, Friedman neurontin S (1957). S AT 5) magnesium dosage stearate hypromelloses triacetin titanium dioxide ferric oxide RED Product Characteristics Color pink Score no score Shape round (biconvex) Size 9mm Flavor Imprint Code 20;Crestor Contains Packaging # Item Code Package Description 1 NDC: tablet. In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required. The total concentration of antibiotic is observed two hours following administration. For more severe infections, 100 mg every 12 hours is recommended. For this reason it is not recommended that children be prescribed Paxil, but doctors may do so at their discretion. In patients with ChildPugh B disease, Cmax and AUC were increased 100 and 21, respectively, compared with patients with normal liver function. 31 Metabolic dosage modulators are classified as S4 substances according to the wada banned substances list. What other drugs will affect doxycycline? 142 events in the rosuvastatin group) with a statistically significant (p.001) relative risk reduction of 44 and absolute risk reduction.2 (see Figure 2). Contents, medical use edit, meldonium may be used to treat coronary artery disease. The developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for zofran and any potential adverse effects on the breast fed infant from zofran or from the underlying maternal condition. The usual neurontin starting dose in adult patients with homozygous familial hypercholesterolemia is 20 mg once daily. Spermatidic giant cells were observed in monkeys after 6month treatment at 30 mg/kg/day in addition to vacuolation of seminiferous tubular epithelium. The drug company Pfizer developed doxycycline in the early 1960s, and the Food and Drug Administration (FDA) approved the drug in 1967 under the brand dosage name Vibramycin. Fluoxetine has been implicated in serious skin rashes and vasculitis (inflammation of small blood vessels).

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Neurontin side effects

Religious in Europe Networking Against Trafficking and Exploitation (RENATE) was established by a group of Religious representing several different congregations working against human trafficking in Europe.

Vision
All people are created in the image of God. We, the Religious of Europe, believe in a world where everyone has a right to human dignity. Human dignity cannot be compromised. Therefore we labour to free the world from trafficking and exploitation.
Goal
To respond in the light of Gospel values to the issue of trafficking of women, children and men.
Objectives
• To develop awareness – raising activities against human trafficking and the growing demand within all levels of society in Europe, using all forms of modern technology and communications;
• Networking and sharing resources, skills and knowledge;
• To research and implement actions against the growing demand for such abuse in the countries of origin and destination.
Membership of RENATE is open to:
• a Religious female/male–working/living in Europe;
• a lay person working with or for Religious in the field of anti-trafficking in Europe;
Friends of RENATE:
• All are welcome to support in different ways: financially, with skills & expertise, prayer etc;
• They may come from all faith traditions or none;
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We invite others to join us in this, God’s Mission.

Ending Trafficking Begins with US.

 

Neurontin side effects

 

Together with Church, State and Civil Society, in conjunction with realising the UN Sustainable Development Goals, RENATE Network is committed to:

• Working tirelessly to rehabilitate victims, free the world of  sexual and labour exploitation, slavery and forced organ harvesting.
• Addressing the root causes of systemic injustice that creates and sustains this vile trade in human lives.
• Using its network to strengthen communication and co-operation between countries of origin, transit and destination.
• Providing opportunities for the full reintegration of victims which can include protection in a safe home, acquisition of proper documents and training for meaningful work so that victims can regain and be enabled to live life to the full.
• Educating society, particularly youth, to view all forms of human trafficking and exploitation as totally unacceptable.
• Challenging judicial and civil authorities to adopt and enforce legislation that protects victims, provides them with adequate compensation, punishes clients and buyers and seizes the assets of perpetrators.
• Collaborating with the media in efforts to bring a strong voice to the attention of the world denouncing all aspects of human trafficking and exploitation.

 

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